Daniel O'Brien
Daniel O'Brien may refer to:
- Daniel O'Brien, 1st Viscount Clare, MP for County Clare, younger son of Connor O'Brien, 3rd Earl of Thomond
- Daniel O'Brien, 3rd Viscount Clare, son of Connor O'Brien, 2nd Viscount Clare
- Daniel O'Brien, 4th Viscount Clare (died 1693), son of Daniel O'Brien, 3rd Viscount Clare
- Dan O'Brien, decathlete
- Dan O'Brien (author)
- Dan O'Brien (baseball executive)
- Dan O'Brien (pitcher) (born 1954), American baseball player, see 1979 St. Louis Cardinals season
- Dan O'Brien Sr. (baseball)
- Dan O'Brien (playwright)
- Dan O'Brien (sports journalist), who is also an author and screenwriter
- Danny O'Brien, English technology journalist
- Danny O'Brien (American football), American college football quarterback
- Daniel O'Brien (comedian), internet comedian and Senior Writer for Cracked